Antidepressants also have about a 40% success rate in improving the quality of life of a patient and come with a laundry list of potential side effects - including suicidal ideation. HRT sits at over 90% and has comparably few side effects outside the actual physical effects hormones cause. The DSM-V recommended treatment for gender dysphoria is HRT, and therapy to treat other symptoms that can occur alongside gender dysphoria.